Cargando…

The effect of memantine, an antagonist of the NMDA glutamate receptor, in in vitro and in vivo infections by Trypanosoma cruzi

Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease that affects 5–6 million people in endemic areas of the Americas. Presently, chemotherapy relies on two compounds that were proposed as trypanocidal drugs four decades ago: nifurtimox and benznidazole. Both drugs are able t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santos Souza, Higo Fernando, Rocha, Sandra Carla, Damasceno, Flávia Silva, Rapado, Ludmila Nakamura, Pral, Elisabeth Mieko Furusho, Marinho, Claudio Romero Farias, Silber, Ariel Mariano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752752/ https://www.ncbi.nlm.nih.gov/pubmed/31536489 http://dx.doi.org/10.1371/journal.pntd.0007226

Ejemplares similares

Memantine, an Antagonist of the NMDA Glutamate Receptor, Affects Cell Proliferation, Differentiation and the Intracellular Cycle and Induces Apoptosis in Trypanosoma cruzi
por: Damasceno, Flávia Silva, et al.
Publicado: (2014)

Proline Dehydrogenase Regulates Redox State and Respiratory Metabolism in Trypanosoma cruzi
por: Paes, Lisvane Silva, et al.
Publicado: (2013)

The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection
por: Crispim, Marcell, et al.
Publicado: (2018)

The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi
por: Magdaleno, Anahí, et al.
Publicado: (2011)

Glutamine Analogues Impair Cell Proliferation, the Intracellular Cycle and Metacyclogenesis in Trypanosoma cruzi
por: Souza, Rodolpho Ornitz Oliveira, et al.
Publicado: (2020)

The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake
por: Merli, Marcelo L., et al.
Publicado: (2016)

Fatty acid oxidation participates in resistance to nutrient-depleted environments in the insect stages of Trypanosoma cruzi
por: Souza, Rodolpho Ornitz Oliveira, et al.
Publicado: (2021)

The Influence of Environmental Cues on the Development of Trypanosoma cruzi in Triatominae Vector
por: Melo, Raíssa de Fátima Pimentel, et al.
Publicado: (2020)

Is Memantine Effective as an NMDA Receptor Antagonist in Adjunctive Therapy for Schizophrenia?
por: Kikuchi, Tetsuro
Publicado: (2020)

Uptake of l-Alanine and Its Distinct Roles in the Bioenergetics of Trypanosoma cruzi
por: Girard, Richard M. B. M., et al.
Publicado: (2018)

Effects of Memantine, an NMDA Antagonist, on Metabolic Syndromes in Female NMRI Mice
por: Osanloo, Naser, et al.
Publicado: (2015)

Correction for Girard et al., “Uptake of l-Alanine and Its Distinct Roles in the Bioenergetics of Trypanosoma cruzi”
por: Girard, Richard M. B. M., et al.
Publicado: (2018)

Proteome-Wide Analysis of Trypanosoma cruzi Exponential and Stationary Growth Phases Reveals a Subcellular Compartment-Specific Regulation
por: Avila, Carla Cristi, et al.
Publicado: (2018)

Computational Modeling of Therapy with the NMDA Antagonist in Neurodegenerative Disease: Information Theory in the Mechanism of Action of Memantine
por: Świetlik, Dariusz, et al.
Publicado: (2022)

Glyceraldehyde 3-Phosphate Dehydrogenase-Telomere Association Correlates with Redox Status in Trypanosoma cruzi
por: Pariona-Llanos, Ricardo, et al.
Publicado: (2015)

Virtual Therapy with the NMDA Antagonist Memantine in Hippocampal Models of Moderate to Severe Alzheimer’s Disease, In Silico Trials
por: Świetlik, Dariusz, et al.
Publicado: (2022)

Nucleosome landscape reflects phenotypic differences in Trypanosoma cruzi life forms
por: Lima, Alex R. J., et al.
Publicado: (2021)

Actions of a Proline Analogue, L-Thiazolidine-4-Carboxylic Acid (T4C), on Trypanosoma cruzi
por: Magdaleno, Anahí, et al.
Publicado: (2009)

An aromatic imidazoline derived from chloroquinoline triggers cell cycle arrest and inhibits with high selectivity the Trypanosoma cruzi mammalian host-cells infection
por: Cuevas-Hernández, Roberto I., et al.
Publicado: (2021)

Immune Evasion Strategies of Trypanosoma cruzi
por: Flávia Nardy, Ana, et al.
Publicado: (2015)

Lizards as Silent Hosts of Trypanosoma cruzi
por: Botto-Mahan, Carezza, et al.
Publicado: (2022)

Using an experimental medicine model to understand the antidepressant potential of the N-Methyl-D-aspartic acid (NMDA) receptor antagonist memantine
por: Pringle, A, et al.
Publicado: (2012)

Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi
por: Shiratsubaki, Isabel S., et al.
Publicado: (2020)

Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity
por: Lopes, João P, et al.
Publicado: (2013)

The effect of the NMDA channel blocker memantine on salicylate-induced tinnitus in rats
por: RALLI, M., et al.
Publicado: (2014)

Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
por: Takahashi, Hiroto, et al.
Publicado: (2015)

In Vitro Validation of Antiparasitic Activity of PLA-Nanoparticles of Sodium Diethyldithiocarbamate against Trypanosoma cruzi
por: de Freitas Oliveira, Johny Wysllas, et al.
Publicado: (2022)

The NMDA antagonist memantine affects training induced motor cortex plasticity – a study using transcranial magnetic stimulation [ISRCTN65784760]
por: Schwenkreis, Peter, et al.
Publicado: (2005)

Glutamate NMDA Receptor Antagonists with Relevance to Schizophrenia: A Review of Zebrafish Behavioral Studies
por: Benvenutti, Radharani, et al.
Publicado: (2022)

Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
por: Takahashi, Hiroto, et al.
Publicado: (2016)

Profiling the Trypanosoma cruzi Phosphoproteome
por: Marchini, Fabricio K., et al.
Publicado: (2011)

Clathrin expression in Trypanosoma cruzi
por: Kalb, Ligia Cristina, et al.
Publicado: (2014)

Endothelial Transmigration by Trypanosoma cruzi
por: Coates, Bria M., et al.
Publicado: (2013)

The N-myristoylome of Trypanosoma cruzi
por: Roberts, Adam J., et al.
Publicado: (2016)

Application of Real-World Data and the REWARD Framework to Detect Unknown Benefits of Memantine and Identify Potential Disease Targets for New NMDA Receptor Antagonists
por: Kern, David M., et al.
Publicado: (2021)

Natural Products as a Source for Treating Neglected Parasitic Diseases
por: Ndjonka, Dieudonné, et al.
Publicado: (2013)

Specific inhibition of the differentiation of Trypanosoma cruzi
Publicado: (1984)

OBSERVATIONS ON THE RESPIRATION OF TRYPANOSOMA CRUZI IN CULTURE
por: von Brand, Theodor, et al.
Publicado: (1946)

Autochthonous Transmission of Trypanosoma cruzi, Louisiana
por: Dorn, Patricia L., et al.
Publicado: (2007)

Flagellar Motility of Trypanosoma cruzi Epimastigotes
por: Ballesteros-Rodea, G., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_jk5jpmg7ntecub32qqlaorkm5k