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MHC binding affects the dynamics of different T-cell receptors in different ways

T cells use their T-cell receptors (TCRs) to scan other cells for antigenic peptides presented by MHC molecules (pMHC). If a TCR encounters a pMHC, it can trigger a signalling pathway that could lead to the activation of the T cell and the initiation of an immune response. It is currently not clear...

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Detalles Bibliográficos
Autores principales: Knapp, Bernhard, van der Merwe, P. Anton, Dushek, Omer, Deane, Charlotte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752857/
https://www.ncbi.nlm.nih.gov/pubmed/31498801
http://dx.doi.org/10.1371/journal.pcbi.1007338