Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes

In breast cancer, tumor hypoxia has been linked to poor prognosis and increased metastasis. Hypoxia activates transcriptional programs in cancer cells that lead to increased motility and invasion, as well as various metabolic changes. One of these metabolic changes, an increase in glycogen metabolis...

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Detalles Bibliográficos
Autores principales: Altemus, Megan A., Goo, Laura E., Little, Andrew C., Yates, Joel A., Cheriyan, Hannah G., Wu, Zhi Fen, Merajver, Sofia D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752868/
https://www.ncbi.nlm.nih.gov/pubmed/31536495
http://dx.doi.org/10.1371/journal.pone.0220973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752868/
https://www.ncbi.nlm.nih.gov/pubmed/31536495
http://dx.doi.org/10.1371/journal.pone.0220973

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