Genetic determinants of cellular addiction to DNA polymerase theta

Polymerase theta (Pol θ, gene name Polq) is a widely conserved DNA polymerase that mediates a microhomology-mediated, error-prone, double strand break (DSB) repair pathway, referred to as Theta Mediated End Joining (TMEJ). Cells with homologous recombination deficiency are reliant on TMEJ for DSB re...

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Detalles Bibliográficos
Autores principales: Feng, Wanjuan, Simpson, Dennis A., Carvajal-Garcia, Juan, Price, Brandon A., Kumar, Rashmi J., Mose, Lisle E., Wood, Richard D., Rashid, Naim, Purvis, Jeremy E., Parker, Joel S., Ramsden, Dale A., Gupta, Gaorav P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753077/
https://www.ncbi.nlm.nih.gov/pubmed/31537809
http://dx.doi.org/10.1038/s41467-019-12234-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753077/
https://www.ncbi.nlm.nih.gov/pubmed/31537809
http://dx.doi.org/10.1038/s41467-019-12234-1

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