Cargando…

Genetic determinants of cellular addiction to DNA polymerase theta

Polymerase theta (Pol θ, gene name Polq) is a widely conserved DNA polymerase that mediates a microhomology-mediated, error-prone, double strand break (DSB) repair pathway, referred to as Theta Mediated End Joining (TMEJ). Cells with homologous recombination deficiency are reliant on TMEJ for DSB re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Wanjuan, Simpson, Dennis A., Carvajal-Garcia, Juan, Price, Brandon A., Kumar, Rashmi J., Mose, Lisle E., Wood, Richard D., Rashid, Naim, Purvis, Jeremy E., Parker, Joel S., Ramsden, Dale A., Gupta, Gaorav P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753077/ https://www.ncbi.nlm.nih.gov/pubmed/31537809 http://dx.doi.org/10.1038/s41467-019-12234-1

Ejemplares similares

Mechanistic basis for microhomology identification and genome scarring by polymerase theta
por: Carvajal-Garcia, Juan, et al.
Publicado: (2020)

Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection
por: Luedeman, Megan E., et al.
Publicado: (2022)

Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency
por: Kumar, Rashmi J, et al.
Publicado: (2020)

DNA polymerase theta suppresses mitotic crossing over
por: Carvajal-Garcia, Juan, et al.
Publicado: (2021)

Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks
por: Feng, Wanjuan, et al.
Publicado: (2021)

Translating transcriptomic findings from cancer model systems to humans through joint dimension reduction
por: Price, Brandon A., et al.
Publicado: (2023)

Low-fidelity DNA synthesis by human DNA polymerase theta
por: Arana, Mercedes E., et al.
Publicado: (2008)

Improved indel detection in DNA and RNA via realignment with ABRA2
por: Mose, Lisle E, et al.
Publicado: (2019)

Polymerase θ inhibition steps on the cGAS pedal
por: Smith, Chelsea M., et al.
Publicado: (2023)

Impact of the DNA polymerase Theta on the DNA replication program
por: Baldacci, Giuseppe, et al.
Publicado: (2014)

Gene targeting in polymerase theta‐deficient Arabidopsis thaliana
por: van Tol, Niels, et al.
Publicado: (2021)

Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation
por: Clay, Delisa E., et al.
Publicado: (2021)

Low-Theta Electroencephalography Coherence Predicts Cigarette Craving in Nicotine Addiction
por: Bu, Junjie, et al.
Publicado: (2019)

Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
por: de Lima, Loyze P., et al.
Publicado: (2019)

Colony-Forming Unit Spreadplate Assay versus Liquid Culture Enrichment-Polymerase Chain Reaction Assay for the Detection of Bacillus Endospores in Soils
por: Griffin, Dale W., et al.
Publicado: (2019)

Intermittent Theta-Burst Stimulation Increases the Working Memory Capacity of Methamphetamine Addicts
por: Sun, Yurong, et al.
Publicado: (2022)

Epstein-Barr Virus-Positive Cancers Show Altered B-Cell Clonality
por: Selitsky, Sara R., et al.
Publicado: (2018)

Rad18 mediates specific mutational signatures and shapes the genomic landscape of carcinogen-induced tumors in vivo
por: Lou, Jitong, et al.
Publicado: (2021)

A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors
por: Zhou, Jia, et al.
Publicado: (2021)

MAKING ANIMALS ALCOHOLIC: SHIFTING LABORATORY MODELS OF ADDICTION
por: RAMSDEN, EDMUND
Publicado: (2015)

Mechanism of Microhomology-Mediated End-Joining Promoted by Human DNA Polymerase Theta
por: Kent, Tatiana, et al.
Publicado: (2015)

ABRA: improved coding indel detection via assembly-based realignment
por: Mose, Lisle E., et al.
Publicado: (2014)

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu
por: Moon, Andrea F., et al.
Publicado: (2017)

BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
por: Kamp, J. A., et al.
Publicado: (2020)

Mindfulness-induced endogenous theta stimulation occasions self-transcendence and inhibits addictive behavior
por: Garland, Eric L., et al.
Publicado: (2022)

Translesion synthesis polymerases are dispensable for C. elegans reproduction but suppress genome scarring by polymerase theta-mediated end joining
por: van Bostelen, Ivo, et al.
Publicado: (2020)

Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair
por: Beagan, Kelly, et al.
Publicado: (2017)

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ
por: Yousefzadeh, Matthew J., et al.
Publicado: (2014)

Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans
por: Roerink, Sophie F., et al.
Publicado: (2014)

Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining
por: van Schendel, Robin, et al.
Publicado: (2016)

A putative Leishmania DNA polymerase theta protects the parasite against oxidative damage
por: Fernández-Orgiler, Abel, et al.
Publicado: (2016)

DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis
por: Smolinska, Agnieszka, et al.
Publicado: (2022)

Altered polymerase theta expression promotes chromosomal instability in salivary adenoid cystic carcinoma
por: Bai, Han, et al.
Publicado: (2022)

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break
por: Kaminski, Andrea M., et al.
Publicado: (2020)

A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis
por: Juárez, Raquel, et al.
Publicado: (2006)

Dissociable Effects of Theta-Burst Repeated Transcranial Magnetic Stimulation to the Inferior Frontal Gyrus on Inhibitory Control in Nicotine Addiction
por: Newman-Norlund, Roger D., et al.
Publicado: (2020)

Mutational signatures of non‐homologous and polymerase theta‐mediated end‐joining in embryonic stem cells
por: Schimmel, Joost, et al.
Publicado: (2017)

The Drosophila melanogaster Ortholog of RFWD3 Functions Independently of RAD51 During DNA Repair
por: Carvajal-Garcia, Juan, et al.
Publicado: (2020)

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway
por: Newman, Joseph A., et al.
Publicado: (2015)

SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling
por: Silva, Grace O., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bg97pc8p40q3q0iovlah1fsnc6