Process development for scale-up production of a therapeutic L-asparaginase by Streptomyces brollosae NEAE-115 from shake flasks to bioreactor

L-asparaginase is a promising enzyme that has a wide range of significant applications including cancer therapy and starchy food industries. The statistical design of Plackett–Burman and face centered central composite design were employed to optimize L-asparaginase production by Streptomyces brollo...

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Detalles Bibliográficos
Autores principales: El-Naggar, Noura El-Ahmady, Moawad, Hassan, El-Shweihy, Nancy M., El-Ewasy, Sara M., Elsehemy, Islam A., Abdelwahed, Nayera A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753079/
https://www.ncbi.nlm.nih.gov/pubmed/31537817
http://dx.doi.org/10.1038/s41598-019-49709-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753079/
https://www.ncbi.nlm.nih.gov/pubmed/31537817
http://dx.doi.org/10.1038/s41598-019-49709-6

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