Central Glucagon-like Peptide-1 Receptor Signaling via Brainstem Catecholamine Neurons Counteracts Hypertension in Spontaneously Hypertensive Rats

Glucagon-like peptide-1 receptor (GLP-1R) agonists, widely used to treat type 2 diabetes, reduce blood pressure (BP) in hypertensive patients. Whether this action involves central mechanisms is unknown. We here report that repeated lateral ventricular (LV) injection of GLP-1R agonist, liraglutide, o...

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Detalles Bibliográficos
Autores principales: Katsurada, Kenichi, Nakata, Masanori, Saito, Toshinobu, Zhang, Boyang, Maejima, Yuko, Nandi, Shyam S., Sharma, Neeru M., Patel, Kaushik P., Kario, Kazuomi, Yada, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753091/
https://www.ncbi.nlm.nih.gov/pubmed/31537818
http://dx.doi.org/10.1038/s41598-019-49364-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753091/
https://www.ncbi.nlm.nih.gov/pubmed/31537818
http://dx.doi.org/10.1038/s41598-019-49364-x

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