Bidirectional transport of 2-chloroadenosine by equilibrative nucleoside transporter 4 (hENT4): Evidence for allosteric kinetics at acidic pH

Adenosine has been reported to be transported by equilibrative nucleoside transporter 4 (ENT4), encoded by the SLC29A4 gene, in an acidic pH-dependent manner. This makes hENT4 of interest as a therapeutic target in acidic pathologies where adenosine is protective (e.g. vascular ischaemia). We examin...

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Detalles Bibliográficos
Autores principales: Tandio, David, Vilas, Gonzalo, Hammond, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753126/
https://www.ncbi.nlm.nih.gov/pubmed/31537831
http://dx.doi.org/10.1038/s41598-019-49929-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753126/
https://www.ncbi.nlm.nih.gov/pubmed/31537831
http://dx.doi.org/10.1038/s41598-019-49929-w

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