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TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells

Recognition of specific chromatin modifications by distinct structural domains within “reader” proteins plays a critical role in the maintenance of genomic stability. However, the specific mechanisms involved in this process remain unclear. Here we report that the PHD-Bromo tandem domain of triparti...

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Detalles Bibliográficos
Autores principales: Chen, Jiajing, Wang, Zikang, Guo, Xudong, Li, Fudong, Wei, Qingtao, Chen, Xuwen, Gong, Deshun, Xu, Yanxin, Chen, Wen, Liu, Yongrui, Kang, Jiuhong, Shi, Yunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753139/
https://www.ncbi.nlm.nih.gov/pubmed/31537782
http://dx.doi.org/10.1038/s41467-019-12126-4