Amyloid β-Induced Upregulation of Na(v)1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer’s Disease Mouse Model

Hyperexcitability and alterations in neuronal networks contribute to cognitive impairment in Alzheimer’s Disease (AD). Voltage-gated sodium channels (Na(V)), which are crucial for regulating neuronal excitability, have been implicated in AD-related hippocampal hyperactivity and higher incidence of s...

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Detalles Bibliográficos
Autores principales: Ciccone, Roselia, Franco, Cristina, Piccialli, Ilaria, Boscia, Francesca, Casamassa, Antonella, de Rosa, Valeria, Cepparulo, Pasquale, Cataldi, Mauro, Annunziato, Lucio, Pannaccione, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753212/
https://www.ncbi.nlm.nih.gov/pubmed/31537873
http://dx.doi.org/10.1038/s41598-019-50018-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753212/
https://www.ncbi.nlm.nih.gov/pubmed/31537873
http://dx.doi.org/10.1038/s41598-019-50018-1

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