Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Even small changes in sequence can alter receptor activation, affecting therapeutic efficacy. We conducted a structure-function relationship study on the neuropeptide TLQP-21, a promising target for obe...

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Detalles Bibliográficos
Autores principales: Sahu, Bhavani S., Rodriguez, Pedro, Nguyen, Megin E., Han, Ruijun, Cero, Cheryl, Razzoli, Maria, Piaggi, Paolo, Laskowski, Lauren J., Pavlicev, Mihaela, Muglia, Louis, Mahata, Sushil K., O’Grady, Scott, McCorvy, John D., Baier, Leslie J., Sham, Yuk Y., Bartolomucci, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753381/
https://www.ncbi.nlm.nih.gov/pubmed/31484069
http://dx.doi.org/10.1016/j.celrep.2019.07.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753381/
https://www.ncbi.nlm.nih.gov/pubmed/31484069
http://dx.doi.org/10.1016/j.celrep.2019.07.101

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