A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay

XRN1 is the major cytoplasmic exoribonuclease in eukaryotes, which degrades deadenylated and decapped mRNAs in the last step of the 5′–3′ mRNA decay pathway. Metazoan XRN1 interacts with decapping factors coupling the final stages of decay. Here, we reveal a direct interaction between XRN1 and the C...

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Detalles Bibliográficos
Autores principales: Chang, Chung-Te, Muthukumar, Sowndarya, Weber, Ramona, Levdansky, Yevgen, Chen, Ying, Bhandari, Dipankar, Igreja, Catia, Wohlbold, Lara, Valkov, Eugene, Izaurralde, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753473/
https://www.ncbi.nlm.nih.gov/pubmed/31340047
http://dx.doi.org/10.1093/nar/gkz633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753473/
https://www.ncbi.nlm.nih.gov/pubmed/31340047
http://dx.doi.org/10.1093/nar/gkz633

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