Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation

Ribonucleotides represent a threat to DNA genome stability and transmission. Two types of Ribonuclease H (RNase H) excise ribonucleotides when they form part of the DNA strand, or hydrolyse RNA when it base-pairs with DNA in structures termed R-loops. Loss of either RNase H is lethal in mammals, whe...

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Detalles Bibliográficos
Autores principales: Briggs, Emma, Crouch, Kathryn, Lemgruber, Leandro, Hamilton, Graham, Lapsley, Craig, McCulloch, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753483/
https://www.ncbi.nlm.nih.gov/pubmed/31350892
http://dx.doi.org/10.1093/nar/gkz644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753483/
https://www.ncbi.nlm.nih.gov/pubmed/31350892
http://dx.doi.org/10.1093/nar/gkz644

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