KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity

CpG islands (CGIs) are associated with the majority of mammalian gene promoters and function to recruit chromatin modifying enzymes. It has therefore been proposed that CGIs regulate gene expression through chromatin-based mechanisms, however in most cases this has not been directly tested. Here, we...

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Detalles Bibliográficos
Autores principales: Turberfield, Anne H, Kondo, Takashi, Nakayama, Manabu, Koseki, Yoko, King, Hamish W, Koseki, Haruhiko, Klose, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753492/
https://www.ncbi.nlm.nih.gov/pubmed/31363749
http://dx.doi.org/10.1093/nar/gkz607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753492/
https://www.ncbi.nlm.nih.gov/pubmed/31363749
http://dx.doi.org/10.1093/nar/gkz607

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