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SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1
Faithful inheritance of DNA methylation across cell division requires DNMT1 and its accessory factor UHRF1. However, how this axis is regulated to ensure DNA methylation homeostasis remains poorly understood. Here we show that SET8, a cell-cycle-regulated protein methyltransferase, controls protein...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753495/ https://www.ncbi.nlm.nih.gov/pubmed/31400111 http://dx.doi.org/10.1093/nar/gkz626 |