SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1

Faithful inheritance of DNA methylation across cell division requires DNMT1 and its accessory factor UHRF1. However, how this axis is regulated to ensure DNA methylation homeostasis remains poorly understood. Here we show that SET8, a cell-cycle-regulated protein methyltransferase, controls protein...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Huifang, Gao, Qinqin, Tan, Shuo, You, Jia, Lyu, Cong, Zhang, Yunpeng, Han, Mengmeng, Chen, Zhaosu, Li, Jialun, Wang, Hailin, Liao, Lujian, Qin, Jun, Li, Jiwen, Wong, Jiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753495/
https://www.ncbi.nlm.nih.gov/pubmed/31400111
http://dx.doi.org/10.1093/nar/gkz626

Ejemplares similares

Ejemplares similares