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Δ(9)-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits
PURPOSE: Δ(9)-Tetrahydrocannabinol-valine-hemisuccinate, a hydrophilic prodrug of Δ(9)-tetrahydrocannabinol, synthesized with the aim of improving the ocular bioavailability of the parent molecule, was investigated in a lipid-based nanoparticle dosage form for ocular delivery. METHODS: Solid lipid n...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753841/ https://www.ncbi.nlm.nih.gov/pubmed/31588378 http://dx.doi.org/10.1167/tvst.8.5.15 |