Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma

Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB). However, SMO-specific antagonists produced mixed results in cl...

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Detalles Bibliográficos
Autores principales: Chahal, Kirti Kandhwal, Li, Jie, Kufareva, Irina, Parle, Milind, Durden, Donald L., Wechsler-Reya, Robert J., Chen, Clark C., Abagyan, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754133/
https://www.ncbi.nlm.nih.gov/pubmed/31539380
http://dx.doi.org/10.1371/journal.pone.0214901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754133/
https://www.ncbi.nlm.nih.gov/pubmed/31539380
http://dx.doi.org/10.1371/journal.pone.0214901

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