Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5

The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases. In this study, we explore the available icariin-derived chemical scaffolds through medicinal chemistry to develop...

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Detalles Bibliográficos
Autores principales: Chau, Yasmin, Li, Fu-Shuang, Levsh, Olesya, Weng, Jing-Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754136/
https://www.ncbi.nlm.nih.gov/pubmed/31539416
http://dx.doi.org/10.1371/journal.pone.0222803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754136/
https://www.ncbi.nlm.nih.gov/pubmed/31539416
http://dx.doi.org/10.1371/journal.pone.0222803

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