Cargando…
Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases. In this study, we explore the available icariin-derived chemical scaffolds through medicinal chemistry to develop...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754136/ https://www.ncbi.nlm.nih.gov/pubmed/31539416 http://dx.doi.org/10.1371/journal.pone.0222803 |