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CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis
In B lymphopoiesis, activation of the pre-B cell antigen receptor (pre-BCR) is associated with both cell cycle exit and Igk recombination. Yet, how the pre-BCR mediates these functions remains unclear. Herein, we demonstrate that the pre-BCR initiated a feed-forward amplification loop mediated by th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754289/ https://www.ncbi.nlm.nih.gov/pubmed/31477919 http://dx.doi.org/10.1038/s41590-019-0468-0 |