Redox-induced structural changes in the di-iron and di-manganese forms of Bacillus anthracis ribonucleotide reductase subunit NrdF suggest a mechanism for gating of radical access

Class Ib ribonucleotide reductases (RNR) utilize a di-nuclear manganese or iron cofactor for reduction of superoxide or molecular oxygen, respectively. This generates a stable tyrosyl radical (Y·) in the R2 subunit (NrdF), which is further used for ribonucleotide reduction in the R1 subunit of RNR....

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Detalles Bibliográficos
Autores principales: Grāve, Kristīne, Lambert, Wietske, Berggren, Gustav, Griese, Julia J., Bennett, Matthew D., Logan, Derek T., Högbom, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754363/
https://www.ncbi.nlm.nih.gov/pubmed/31410573
http://dx.doi.org/10.1007/s00775-019-01703-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754363/
https://www.ncbi.nlm.nih.gov/pubmed/31410573
http://dx.doi.org/10.1007/s00775-019-01703-z

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