VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

The mucus layer is the first line of innate host defense in the gut that protects the epithelium by spatially separating commensal bacteria. MUC2 mucin is produced and stored by goblet cells that is constitutively exocytosed or hyper secreted upon sensing a threat. How coordinated mucus exocytosis m...

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Detalles Bibliográficos
Autores principales: Cornick, Steve, Kumar, Manish, Moreau, France, Gaisano, Herbert, Chadee, Kris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754373/
https://www.ncbi.nlm.nih.gov/pubmed/31541089
http://dx.doi.org/10.1038/s41467-019-11811-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754373/
https://www.ncbi.nlm.nih.gov/pubmed/31541089
http://dx.doi.org/10.1038/s41467-019-11811-8

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