Homomeric GluA2(R) AMPA receptors can conduct when desensitized

Desensitization is a canonical property of ligand-gated ion channels, causing progressive current decline in the continued presence of agonist. AMPA-type glutamate receptors (AMPARs), which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization. Recent cryo-EM studi...

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Detalles Bibliográficos
Autores principales: Coombs, Ian D., Soto, David, McGee, Thomas P., Gold, Matthew G., Farrant, Mark, Cull-Candy, Stuart G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754398/
https://www.ncbi.nlm.nih.gov/pubmed/31541113
http://dx.doi.org/10.1038/s41467-019-12280-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754398/
https://www.ncbi.nlm.nih.gov/pubmed/31541113
http://dx.doi.org/10.1038/s41467-019-12280-9

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