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A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins
Histone post-translational modifications (PTMs) contribute to chromatin accessibility due to their chemical properties and their ability to recruit enzymes responsible for DNA readout and chromatin remodeling. To date, more than 400 different histone PTMs and thousands of combinations of PTMs have b...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754405/ https://www.ncbi.nlm.nih.gov/pubmed/31541121 http://dx.doi.org/10.1038/s41598-019-49894-4 |