Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD

It is well settled that the amyloidogenic properties of the plasma protein transporter transthyretin (TTR) can be modulated by compounds that stabilize its native tetrameric conformation. TTR is also present in cerebrospinal fluid where it can bind to Aβ-peptides and prevent Aβ aggregation. We have...

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Detalles Bibliográficos
Autores principales: Rios, Xabier, Gómez-Vallejo, Vanessa, Martín, Abraham, Cossío, Unai, Morcillo, Miguel Ángel, Alemi, Mobina, Cardoso, Isabel, Quintana, Jordi, Jiménez-Barbero, Jesús, Cotrina, Ellen Y., Valencia, Gregorio, Arsequell, Gemma, Llop, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754432/
https://www.ncbi.nlm.nih.gov/pubmed/31541162
http://dx.doi.org/10.1038/s41598-019-50071-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754432/
https://www.ncbi.nlm.nih.gov/pubmed/31541162
http://dx.doi.org/10.1038/s41598-019-50071-w

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