Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma

Severe blunt trauma is associated with an early ‘genomic storm’ which causes simultaneous up- and down-regulation of host protective immunity. Excessive inflammation can lead to organ injury. In the absence of infection, the inflammatory response is presumably driven by release of endogenous alarmin...

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Detalles Bibliográficos
Autores principales: Stortz, Julie A., Hawkins, Russell B., Holden, David C., Raymond, Steven L., Wang, Zhongkai, Brakenridge, Scott C., Cuschieri, Joseph, Moore, Frederick A., Maier, Ronald V., Moldawer, Lyle L., Efron, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754448/
https://www.ncbi.nlm.nih.gov/pubmed/31541163
http://dx.doi.org/10.1038/s41598-019-50044-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754448/
https://www.ncbi.nlm.nih.gov/pubmed/31541163
http://dx.doi.org/10.1038/s41598-019-50044-z

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