Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

β-Lactamases are a major threat to the clinical use of carbapenems, which are often antibiotics of last resort. Despite this, the reaction outcomes and mechanisms by which β-lactamases degrade carbapenems are still not fully understood. The carbapenem bicyclic core consists of a β-lactam ring fused...

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Detalles Bibliográficos
Autores principales: Lohans, Christopher T., Freeman, Emily I., Groesen, Emma van, Tooke, Catherine L., Hinchliffe, Philip, Spencer, James, Brem, Jürgen, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754457/
https://www.ncbi.nlm.nih.gov/pubmed/31541180
http://dx.doi.org/10.1038/s41598-019-49264-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754457/
https://www.ncbi.nlm.nih.gov/pubmed/31541180
http://dx.doi.org/10.1038/s41598-019-49264-0

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