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Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation
β-Lactamases are a major threat to the clinical use of carbapenems, which are often antibiotics of last resort. Despite this, the reaction outcomes and mechanisms by which β-lactamases degrade carbapenems are still not fully understood. The carbapenem bicyclic core consists of a β-lactam ring fused...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754457/ https://www.ncbi.nlm.nih.gov/pubmed/31541180 http://dx.doi.org/10.1038/s41598-019-49264-0 |