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Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction

Glucagon promotes hepatic gluconeogenesis and maintains whole-body glucose levels during fasting. The regulatory factors that are involved in fasting glucagon response are not well understood. Here we report a role of p52, a key activator of the noncanonical nuclear factor-kappaB signaling, in hepat...

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Detalles Bibliográficos
Autores principales: Zhang, Wen-Song, Pan, An, Zhang, Xu, Ying, Ang, Ma, Gaoxiang, Liu, Bao-Lin, Qi, Lian-Wen, Liu, Qun, Li, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754499/
https://www.ncbi.nlm.nih.gov/pubmed/31541100
http://dx.doi.org/10.1038/s41467-019-12351-x