The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy

Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein. Because TP53 inactivating mutations, frequently found in human tumors, could interfere with Granz...

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Detalles Bibliográficos
Autores principales: Chollat-Namy, Marie, Ben Safta-Saadoun, Thouraya, Haferssas, Djazia, Meurice, Guillaume, Chouaib, Salem, Thiery, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754511/
https://www.ncbi.nlm.nih.gov/pubmed/31541080
http://dx.doi.org/10.1038/s41419-019-1950-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754511/
https://www.ncbi.nlm.nih.gov/pubmed/31541080
http://dx.doi.org/10.1038/s41419-019-1950-1

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