Overproduction of H(2)S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and subsequent overproduction of the gaseous transm...

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Detalles Bibliográficos
Autores principales: Panagaki, Theodora, Randi, Elisa B., Augsburger, Fiona, Szabo, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754544/
https://www.ncbi.nlm.nih.gov/pubmed/31481613
http://dx.doi.org/10.1073/pnas.1911895116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754544/
https://www.ncbi.nlm.nih.gov/pubmed/31481613
http://dx.doi.org/10.1073/pnas.1911895116

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