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Systematic minimization of RNA ligase ribozyme through large-scale design-synthesis-sequence cycles
Template-directed RNA ligation catalyzed by an RNA enzyme (ribozyme) is a plausible and important reaction that could have been involved in transferring genetic information during prebiotic evolution. Laboratory evolution experiments have yielded several classes of ligase ribozymes, but their minima...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755084/ https://www.ncbi.nlm.nih.gov/pubmed/31504757 http://dx.doi.org/10.1093/nar/gkz729 |