Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage

Overcoming lysogenization defect (OLD) proteins constitute a family of uncharacterized nucleases present in bacteria, archaea, and some viruses. These enzymes contain an N-terminal ATPase domain and a C-terminal Toprim domain common amongst replication, recombination, and repair proteins. The in viv...

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Detalles Bibliográficos
Autores principales: Schiltz, Carl J, Lee, April, Partlow, Edward A, Hosford, Christopher J, Chappie, Joshua S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755086/
https://www.ncbi.nlm.nih.gov/pubmed/31400118
http://dx.doi.org/10.1093/nar/gkz703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755086/
https://www.ncbi.nlm.nih.gov/pubmed/31400118
http://dx.doi.org/10.1093/nar/gkz703

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