Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial-mesenchymal transition

The aberrant expression of tumor suppressor Smad4 often occurs in colorectal cancer (CRC), and this phenomenon is believed to be associated with drug resistance. The present study aimed to investigate the effects of Smad4 on the sensitivity of CRC cells to cetuximab, and the possible mechanism under...

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Detalles Bibliográficos
Autores principales: Lin, Zhenlv, Zhang, Lin, Zhou, Junfeng, Zheng, Jiantao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755154/
https://www.ncbi.nlm.nih.gov/pubmed/31485652
http://dx.doi.org/10.3892/mmr.2019.10597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755154/
https://www.ncbi.nlm.nih.gov/pubmed/31485652
http://dx.doi.org/10.3892/mmr.2019.10597

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