Excessive Accumulation of Ca(2 +) in Mitochondria of Y522S-RYR1 Knock-in Mice: A Link Between Leak From the Sarcoplasmic Reticulum and Altered Redox State

Mice (Y522S or YS), carrying a mutation of the sarcoplasmic reticulum (SR) Ca(2+) release channel of skeletal muscle fibers (ryanodine receptor type-1, RyR1) which causes Ca(2+) leak, are a widely accepted and intensively studied model for human malignant hyperthermia (MH) susceptibility. Since the...

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Detalles Bibliográficos
Autores principales: Canato, Marta, Capitanio, Paola, Cancellara, Lina, Leanza, Luigi, Raffaello, Anna, Reane, Denis Vecellio, Marcucci, Lorenzo, Michelucci, Antonio, Protasi, Feliciano, Reggiani, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755340/
https://www.ncbi.nlm.nih.gov/pubmed/31607937
http://dx.doi.org/10.3389/fphys.2019.01142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755340/
https://www.ncbi.nlm.nih.gov/pubmed/31607937
http://dx.doi.org/10.3389/fphys.2019.01142

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