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Excessive Accumulation of Ca(2 +) in Mitochondria of Y522S-RYR1 Knock-in Mice: A Link Between Leak From the Sarcoplasmic Reticulum and Altered Redox State
Mice (Y522S or YS), carrying a mutation of the sarcoplasmic reticulum (SR) Ca(2+) release channel of skeletal muscle fibers (ryanodine receptor type-1, RyR1) which causes Ca(2+) leak, are a widely accepted and intensively studied model for human malignant hyperthermia (MH) susceptibility. Since the...
Autores principales: | Canato, Marta, Capitanio, Paola, Cancellara, Lina, Leanza, Luigi, Raffaello, Anna, Reane, Denis Vecellio, Marcucci, Lorenzo, Michelucci, Antonio, Protasi, Feliciano, Reggiani, Carlo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755340/ https://www.ncbi.nlm.nih.gov/pubmed/31607937 http://dx.doi.org/10.3389/fphys.2019.01142 |
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