Evaluation of Continuous Tumor-Size–Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

IMPORTANCE: Tumor measurements can be used to estimate time to nadir and depth of nadir as potential surrogates for overall survival (OS). OBJECTIVE: To assess time to nadir and depth of nadir as surrogates for OS in metastatic colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS: Pooled analysis of...

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Detalles Bibliográficos
Autores principales: Burzykowski, Tomasz, Coart, Elisabeth, Saad, Everardo D., Shi, Qian, Sommeijer, Dirkje W., Bokemeyer, Carsten, Díaz-Rubio, Eduardo, Douillard, Jean-Yves, Falcone, Alfredo, Fuchs, Charles S., Goldberg, Richard M., Hecht, J. Randolph, Hoff, Paulo M., Hurwitz, Herbert, Kabbinavar, Fairooz F., Koopman, Miriam, Maughan, Timothy S., Punt, Cornelis J. A., Saltz, Leonard, Schmoll, Hans-Joachim, Seymour, Matthew T., Tebbutt, Niall C., Tournigand, Christophe, Van Cutsem, Eric, de Gramont, Aimery, Zalcberg, John R., Buyse, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2019
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755539/
https://www.ncbi.nlm.nih.gov/pubmed/31539075
http://dx.doi.org/10.1001/jamanetworkopen.2019.11750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755539/
https://www.ncbi.nlm.nih.gov/pubmed/31539075
http://dx.doi.org/10.1001/jamanetworkopen.2019.11750

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