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Perampanel inhibits calcitonin gene-related peptide release from rat brainstem in vitro

BACKGROUND: Perampanel is a novel antiepileptic drug acting via non-competitive antagonism on glutamatergic AMPA receptors, and the subsequent inhibition of ion calcium influx. Since it was recently postulated that the antagonists of glutamate receptors might play a role in the treatment of migraine...

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Detalles Bibliográficos
Autores principales: Tringali, Giuseppe, Currò, Diego, Navarra, Pierluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755590/
https://www.ncbi.nlm.nih.gov/pubmed/30419806
http://dx.doi.org/10.1186/s10194-018-0940-5