Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae

Neisseria gonorrhoeae responds to host-derived antimicrobials by inducing the expression of the mtrCDE-encoded multidrug efflux pump, which expels microbicides, such as bile salts, fatty acids, and multiple extrinsically administered drugs, from the cell. In the absence of these cytotoxins, the TetR...

Descripción completa

Detalles Bibliográficos
Autores principales: Beggs, Grace A., Zalucki, Yaramah M., Brown, Nicholas Gene, Rastegari, Sheila, Phillips, Rebecca K., Palzkill, Timothy, Shafer, William M., Kumaraswami, Muthiah, Brennan, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755732/
https://www.ncbi.nlm.nih.gov/pubmed/31331979
http://dx.doi.org/10.1128/JB.00401-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755732/
https://www.ncbi.nlm.nih.gov/pubmed/31331979
http://dx.doi.org/10.1128/JB.00401-19

Ejemplares similares