Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor

Tamoxifen has been used for many years to target estrogen receptor signalling in breast cancer cells. Tamoxifen is also an agonist of the G protein-coupled estrogen receptor (GPER), a GPCR ubiquitously expressed in tissues that mediates the acute response to estrogens. Here we report that tamoxifen...

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Detalles Bibliográficos
Autores principales: Cortes, Ernesto, Lachowski, Dariusz, Rice, Alistair, Thorpe, Stephen D., Robinson, Benjamin, Yeldag, Gulcen, Lee, David A., Ghemtio, Leo, Rombouts, Krista, del Río Hernández, Armando E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755965/
https://www.ncbi.nlm.nih.gov/pubmed/30575816
http://dx.doi.org/10.1038/s41388-018-0631-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755965/
https://www.ncbi.nlm.nih.gov/pubmed/30575816
http://dx.doi.org/10.1038/s41388-018-0631-3

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