The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases

How cells in primary tumors initially become pro-metastatic is not understood. A previous genome-wide RNAi screen uncovered colon cancer metastatic suppressor and WNT promoting functions of TMED3, a member of the p24 ER-to-Golgi protein secretion family. Repression of canonical WNT signaling upon kn...

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Detalles Bibliográficos
Autores principales: Mishra, Sonakshi, Bernal, Carolina, Silvano, Marianna, Anand, Santosh, Ruiz i Altaba, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755966/
https://www.ncbi.nlm.nih.gov/pubmed/31253868
http://dx.doi.org/10.1038/s41388-019-0845-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755966/
https://www.ncbi.nlm.nih.gov/pubmed/31253868
http://dx.doi.org/10.1038/s41388-019-0845-z

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