Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness

The global downregulation of microRNAs (miRNAs) is emerging as a common hallmark of cancer. However, the mechanisms underlying this phenomenon are not well known. We identified that the oncogenic miR-146b-5p attenuates miRNA biosynthesis by targeting DICER1 and reducing its expression. DICER1 overex...

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Detalles Bibliográficos
Autores principales: Ramírez-Moya, Julia, Wert-Lamas, León, Riesco-Eizaguirre, Garcilaso, Santisteban, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755984/
https://www.ncbi.nlm.nih.gov/pubmed/30967628
http://dx.doi.org/10.1038/s41388-019-0804-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755984/
https://www.ncbi.nlm.nih.gov/pubmed/30967628
http://dx.doi.org/10.1038/s41388-019-0804-8

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