Cargando…
Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness
The global downregulation of microRNAs (miRNAs) is emerging as a common hallmark of cancer. However, the mechanisms underlying this phenomenon are not well known. We identified that the oncogenic miR-146b-5p attenuates miRNA biosynthesis by targeting DICER1 and reducing its expression. DICER1 overex...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755984/ https://www.ncbi.nlm.nih.gov/pubmed/30967628 http://dx.doi.org/10.1038/s41388-019-0804-8 |