Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer

Genomic alterations in cancer cells result in vulnerabilities that clinicians can exploit using molecularly targeted drugs, guided by knowledge of the tumour genotype. However, the selective activity of these drugs exerts an evolutionary pressure on cancers that can result in the outgrowth of resist...

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Detalles Bibliográficos
Autores principales: Clarke, Paul A., Roe, Toby, Swabey, Kate, Hobbs, Steve M., McAndrew, Craig, Tomlin, Kathy, Westwood, Isaac, Burke, Rosemary, van Montfort, Robert, Workman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755994/
https://www.ncbi.nlm.nih.gov/pubmed/30905967
http://dx.doi.org/10.1038/s41388-019-0780-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755994/
https://www.ncbi.nlm.nih.gov/pubmed/30905967
http://dx.doi.org/10.1038/s41388-019-0780-z

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