Cargando…

Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism

The Bcl-2-associated death promoter BAD is a prognostic indicator for good clinical outcome of breast cancer patients; however, whether BAD affects breast cancer biology is unknown. Here we showed that BAD increased cell growth in breast cancer cells through two distinct mechanisms. Phosphorylation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mann, Jasdeep, Githaka, John Maringa, Buckland, Timothy W., Yang, Ning, Montpetit, Rachel, Patel, Namrata, Li, Lei, Baksh, Shairaz, Godbout, Roseline, Lemieux, Hélène, Goping, Ing Swie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756016/ https://www.ncbi.nlm.nih.gov/pubmed/30635657 http://dx.doi.org/10.1038/s41388-018-0673-6

Ejemplares similares

BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis
por: Mann, Jasdeep, et al.
Publicado: (2020)

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models
por: Githaka, John Maringa, et al.
Publicado: (2021)

Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis
por: Yang, Ning, et al.
Publicado: (2017)

BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer
por: Pandya, Vrajesh, et al.
Publicado: (2020)

The Rubella Virus Capsid Is an Anti-Apoptotic Protein that Attenuates the Pore-Forming Ability of Bax
por: Ilkow, Carolina S., et al.
Publicado: (2011)

Molnupiravir Does Not Induce Mutagenesis in Host Lung Cells during SARS-CoV-2 Treatment
por: Githaka, John Maringa
Publicado: (2022)

The pro-apoptotic paradox: the BH3-only protein Bcl-2 interacting killer (Bik) is prognostic for unfavorable outcomes in breast cancer
por: Pandya, Vrajesh, et al.
Publicado: (2016)

Lysophosphatidate Induces Chemo-Resistance by Releasing Breast Cancer Cells from Taxol-Induced Mitotic Arrest
por: Samadi, Nasser, et al.
Publicado: (2011)

Characterization of the Apoptotic Response Induced by the Cyanine Dye D112: A Potentially Selective Anti-Cancer Compound
por: Yang, Ning, et al.
Publicado: (2015)

Modulator of Apoptosis 1: A Highly Regulated RASSF1A-Interacting BH3-Like Protein
por: Law, Jennifer, et al.
Publicado: (2012)

Robust inflammatory breast cancer gene signature using nonparametric random forest analysis
por: Zare, Alaa, et al.
Publicado: (2021)

Regulated Targeting of BAX to Mitochondria
por: Goping, Ing Swie, et al.
Publicado: (1998)

Granzyme B–Mediated Cytochrome C Release Is Regulated by the Bcl-2 Family Members Bid and Bax
por: Heibein, Jeffrey A., et al.
Publicado: (2000)

Tumor necrosis factor α-induced protein 3 (A20) is dysregulated in pediatric Crohn disease
por: Zaidi, Deenaz, et al.
Publicado: (2018)

Chlorogenic acid alleviates the reduction of Akt and Bad phosphorylation and of phospho-Bad and 14-3-3 binding in an animal model of stroke
por: Shah, Murad-Ali, et al.
Publicado: (2022)

RASSF1 Polymorphisms in Cancer
por: Gordon, Marilyn, et al.
Publicado: (2012)

Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells
por: Thiery, Jerome, et al.
Publicado: (2011)

Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis
por: Nakamura, Kimitoshi, et al.
Publicado: (2000)

Calreticulin inhibits commitment to adipocyte differentiation
por: Szabo, Eva, et al.
Publicado: (2008)

RASSF Family Proteins
por: Clark, Geoffrey J., et al.
Publicado: (2012)

Calreticulin inhibits commitment to adipocyte differentiation
por: Szabo, Eva, et al.
Publicado: (2015)

The Na(+) /H(+) exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells
por: Amith, Schammim Ray, et al.
Publicado: (2014)

Latent Cytomegalovirus Infection in Female Mice Increases Breast Cancer Metastasis
por: Yang, Zelei, et al.
Publicado: (2019)

Canonical and non-canonical functions of NLRP3
por: Accogli, Théo, et al.
Publicado: (2023)

ω-3 and ω-6 Fatty Acids Modulate Conventional and Atypical Protein Kinase C Activities in a Brain Fatty Acid Binding Protein Dependent Manner in Glioblastoma Multiforme
por: Elsherbiny, Marwa E., et al.
Publicado: (2018)

Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-X(L)
por: Macdonald, Andrew, et al.
Publicado: (2006)

An Amplified Fatty Acid-Binding Protein Gene Cluster in Prostate Cancer: Emerging Roles in Lipid Metabolism and Metastasis
por: Liu, Rong-Zong, et al.
Publicado: (2020)

Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors
por: Alvarez, Reinier, et al.
Publicado: (2021)

MLN64 Transport to the Late Endosome Is Regulated by Binding to 14-3-3 via a Non-canonical Binding Site
por: Liapis, Anastasia, et al.
Publicado: (2012)

RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis
por: Zare, Alaa, et al.
Publicado: (2018)

Erratum: Zare, A. et al. RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis. Cancers, 2018, 10, 184
por: Zare, Alaa, et al.
Publicado: (2018)

Bad research is not all bad
por: Hamilton, Fergus, et al.
Publicado: (2023)

Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation
por: Ahn, Huijeong, et al.
Publicado: (2018)

Vetoing bad momentum resolution muons for Run 3
por: Shelestiuk, Oleksandr
Publicado: (2022)

The “Canone Inverso”: when tobacco was not so bad. A look back at the primordial debate on the tobacco effects in the occupational medicine
por: Marinozzi, Silvia, et al.
Publicado: (2018)

Is Screening of TORCH Worthwhile in Women with Bad Obstetric History: An Observation from Eastern Nepal
por: Kumari, Namrata, et al.
Publicado: (2011)

The FABP12/PPARγ pathway promotes metastatic transformation by inducing epithelial‐to‐mesenchymal transition and lipid‐derived energy production in prostate cancer cells
por: Liu, Rong‐Zong, et al.
Publicado: (2020)

Convergence of Canonical and Non-canonical Wnt Signal: Differential Kat3 Coactivator Usage
por: Lai, Keane K.Y., et al.
Publicado: (2019)

Stuck in a lockdown: Dreams, bad dreams, nightmares, and their relationship to stress, depression and anxiety during the COVID-19 pandemic
por: Solomonova, Elizaveta, et al.
Publicado: (2021)

Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells
por: Li, Lin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lp0r4vqf2h118lfv5hvchd43so