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Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma

The underlying forces that shape mutational patterns within any type of cancer have been poorly characterized. One of the best preserved exclusionary relationships is that between BRAF(V600E) and NRAS(Q61) in melanomas. To explore possible mechanisms which could explain this phenomenon, we overexpre...

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Detalles Bibliográficos
Autores principales: Kumar, Raj, Njauw, Ching-Ni, Reddy, Bobby Y., Ji, Zhenyu, Rajadurai, Anpuchchelvi, Klebanov, Nikolai, Tsao, Hensin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756020/
https://www.ncbi.nlm.nih.gov/pubmed/30651601
http://dx.doi.org/10.1038/s41388-018-0632-2