Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab

Anterior gradient 2 (AGR2), a protein belonging to the protein disulfide isomerase (PDI) family, is overexpressed in multiple cancers and promotes angiogenesis to drive cancer progression. The mechanisms controlling AGR2 abundance in cancer remain largely unknown. Here, we observed that AGR2 express...

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Detalles Bibliográficos
Autores principales: Wang, Dawei, Xu, Qingqing, Yuan, Quan, Jia, Mengqi, Niu, Huanmin, Liu, Xiaofei, Zhang, Jinsan, Young, Charles Yf, Yuan, Huiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756021/
https://www.ncbi.nlm.nih.gov/pubmed/30647455
http://dx.doi.org/10.1038/s41388-019-0675-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756021/
https://www.ncbi.nlm.nih.gov/pubmed/30647455
http://dx.doi.org/10.1038/s41388-019-0675-z

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