Cargando…
A Sox2–Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells
Increased cancer stem cell content during development of resistance to tamoxifen in breast cancer is driven by multiple signals, including Sox2-dependent activation of Wnt signalling. Here, we show that Sox2 increases and estrogen reduces the expression of the transcription factor Sox9. Gain and los...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756022/ https://www.ncbi.nlm.nih.gov/pubmed/30622340 http://dx.doi.org/10.1038/s41388-018-0656-7 |