Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers

Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the BCL-2 dependency of luminal tumor cells is nevertheless mitigated by breast cancer-associated fibroblasts (bCAFs) in a manner that defines MCL-1...

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Detalles Bibliográficos
Autores principales: Louault, K., Bonneaud, T. L, Séveno, C., Gomez-Bougie, P., Nguyen, F., Gautier, F., Bourgeois, N., Loussouarn, D., Kerdraon, O., Barillé-Nion, S., Jézéquel, P., Campone, M., Amiot, M., Juin, P. P., Souazé, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756023/
https://www.ncbi.nlm.nih.gov/pubmed/30631150
http://dx.doi.org/10.1038/s41388-018-0635-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756023/
https://www.ncbi.nlm.nih.gov/pubmed/30631150
http://dx.doi.org/10.1038/s41388-018-0635-z

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